Lymph drainage studied by lymphoscintigraphy in the arms after sentinel node biopsy compared with axillary lymph node dissection following conservative breast cancer surgery
Identifieur interne : 007746 ( Main/Exploration ); précédent : 007745; suivant : 007747Lymph drainage studied by lymphoscintigraphy in the arms after sentinel node biopsy compared with axillary lymph node dissection following conservative breast cancer surgery
Auteurs : F. Celebioglu [Suède] ; L. Perbeck ; J. Frisell ; E. Grondal ; L. Svensson ; R. DanielssonSource :
- Acta radiologica : (1987) [ 0284-1851 ] ; 2007.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Aisselle, Biopsie de noeud lymphatique sentinelle, Bras (imagerie diagnostique), Femelle, Humains, Lymphadénectomie, Lymphe (physiologie), Lymphoedème (imagerie diagnostique), Mastectomie partielle, Scintigraphie, Tumeurs du sein (), Tumeurs du sein (anatomopathologie), Tumeurs du sein (imagerie diagnostique).
- MESH :
- anatomopathologie : Tumeurs du sein.
- imagerie diagnostique : Bras, Lymphoedème, Tumeurs du sein.
- physiologie : Lymphe.
- Pascal (Inist)
- Adulte d'âge moyen, Aisselle, Biopsie de noeud lymphatique sentinelle, Femelle, Humains, Lymphadénectomie, Lymphoedème, Carcinome sein, Biopsie, Mastectomie partielle, Radiothérapie, Scintigraphie, Système lymphatique, Bras, Ganglion sentinelle, Etude comparative, Ganglion lymphatique, Chirurgie conservatrice, Tumeurs du sein, Volume, Glande mammaire, Sein, Peau, Avant bras, Derme, Creux axillaire, Traitement, Cancer du sein.
English descriptors
- KwdEn :
- Arm, Arm (diagnostic imaging), Axilla, Biopsy, Breast, Breast Neoplasms (diagnostic imaging), Breast Neoplasms (pathology), Breast Neoplasms (therapy), Breast cancer, Breast carcinoma, Comparative study, Conservative surgery, Derm, Female, Forearm, Humans, Lymph (physiology), Lymph Node Excision, Lymph node, Lymphatic system, Lymphedema, Lymphedema (diagnostic imaging), Mammary gland, Mastectomy, Segmental, Middle Aged, Radionuclide Imaging, Radiotherapy, Sentinel Lymph Node Biopsy, Sentinel lymph node, Skin, Treatment, Volume.
- MESH :
- diagnostic imaging : Arm, Breast Neoplasms, Lymphedema.
- pathology : Breast Neoplasms.
- physiology : Lymph.
- therapy : Breast Neoplasms.
- Axilla, Female, Humans, Lymph Node Excision, Mastectomy, Segmental, Middle Aged, Radionuclide Imaging, Sentinel Lymph Node Biopsy.
Abstract
Purpose: To investigate lymphatic drainage as measured by lymphoscintigraphy in the arms of patients undergoing either sentinel lymph node biopsy (SNB) or axillary lymph node dissection (ALND). Material and Methods: From January 2001 to December 2002, 30 patients with unilateral invasive breast carcinoma underwent breast-conserving surgery with SNB and 30 patients with ALND. All patients received radiotherapy to the breast. Lymphoscintigraphy was performed, and skin circulation, skin temperature, and arm volume were measured 2-3 years after radiotherapy. Results: None of the 30 patients who underwent SNB showed any clinical manifestation of lymphedema. Of the 30 patients undergoing ALND, six (20%) had clinical lymphedema, with an arm volume that was >10% larger on the operated than on the non-operated side (P<0.01). Scintigraphically, visual analysis revealed lymphatic dysfunction in three patients, manifested as forearm dermal back flow. Two of these patients also had an increased arm volume. Quantitative analysis showed no differences between the groups, apart from a smaller amount of isotope in the axilla in the ALND group. There was no difference in skin circulation or skin temperature. Conclusion: Our study shows that lymph drainage in the operated arm compared with the non-operated arm was less affected by SNB than by ALND, and that morbidity associated with SNB was lower than with ALND. However, the results do not confirm our hypothesis that lymphoscintigraphy can reveal differences in lymph circulation that are not evident clinically in the form of manifest lymphedema. The most sensitive clinical method of assessing lymph drainage seems to be measurement of arm volume.
Affiliations:
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Celebioglu</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital Solna</s1><s2>Stockholm</s2><s3>SWE</s3></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Radiology, Department of Clinical Science, Intervention, and Technology (CLINTEC), Karolinska Institute, Karolinska University Hospital</s1><s2>Huddinge</s2><s3>SWE</s3></inist:fA14><country>Suède</country><wicri:noRegion>Huddinge</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Medical Physics, Karolinska University Hospital</s1><s2>Huddinge</s2><s3>SWE</s3></inist:fA14><country>Suède</country><wicri:noRegion>Huddinge</wicri:noRegion></affiliation></author><author><name sortKey="Perbeck, L" sort="Perbeck, L" uniqKey="Perbeck L" first="L." last="Perbeck">L. Perbeck</name></author><author><name sortKey="Frisell, J" sort="Frisell, J" uniqKey="Frisell J" first="J." last="Frisell">J. Frisell</name></author><author><name sortKey="Grondal, E" sort="Grondal, E" uniqKey="Grondal E" first="E." last="Grondal">E. Grondal</name></author><author><name sortKey="Svensson, L" sort="Svensson, L" uniqKey="Svensson L" first="L." last="Svensson">L. Svensson</name></author><author><name sortKey="Danielsson, R" sort="Danielsson, R" uniqKey="Danielsson R" first="R." last="Danielsson">R. Danielsson</name></author></analytic><series><title level="j" type="main">Acta radiologica : (1987)</title><title level="j" type="abbreviated">Acta radiol. : (1987)</title><idno type="ISSN">0284-1851</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Acta radiologica : (1987)</title><title level="j" type="abbreviated">Acta radiol. : (1987)</title><idno type="ISSN">0284-1851</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arm</term><term>Arm (diagnostic imaging)</term><term>Axilla</term><term>Biopsy</term><term>Breast</term><term>Breast Neoplasms (diagnostic imaging)</term><term>Breast Neoplasms (pathology)</term><term>Breast Neoplasms (therapy)</term><term>Breast cancer</term><term>Breast carcinoma</term><term>Comparative study</term><term>Conservative surgery</term><term>Derm</term><term>Female</term><term>Forearm</term><term>Humans</term><term>Lymph (physiology)</term><term>Lymph Node Excision</term><term>Lymph node</term><term>Lymphatic system</term><term>Lymphedema</term><term>Lymphedema (diagnostic imaging)</term><term>Mammary gland</term><term>Mastectomy, Segmental</term><term>Middle Aged</term><term>Radionuclide Imaging</term><term>Radiotherapy</term><term>Sentinel Lymph Node Biopsy</term><term>Sentinel lymph node</term><term>Skin</term><term>Treatment</term><term>Volume</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Aisselle</term><term>Biopsie de noeud lymphatique sentinelle</term><term>Bras (imagerie diagnostique)</term><term>Femelle</term><term>Humains</term><term>Lymphadénectomie</term><term>Lymphe (physiologie)</term><term>Lymphoedème (imagerie diagnostique)</term><term>Mastectomie partielle</term><term>Scintigraphie</term><term>Tumeurs du sein ()</term><term>Tumeurs du sein (anatomopathologie)</term><term>Tumeurs du sein (imagerie diagnostique)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Arm</term><term>Breast Neoplasms</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Bras</term><term>Lymphoedème</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Lymphe</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymph</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Axilla</term><term>Female</term><term>Humans</term><term>Lymph Node Excision</term><term>Mastectomy, Segmental</term><term>Middle Aged</term><term>Radionuclide Imaging</term><term>Sentinel Lymph Node Biopsy</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Aisselle</term><term>Biopsie de noeud lymphatique sentinelle</term><term>Femelle</term><term>Humains</term><term>Lymphadénectomie</term><term>Lymphoedème</term><term>Carcinome sein</term><term>Biopsie</term><term>Mastectomie partielle</term><term>Radiothérapie</term><term>Scintigraphie</term><term>Système lymphatique</term><term>Bras</term><term>Ganglion sentinelle</term><term>Etude comparative</term><term>Ganglion lymphatique</term><term>Chirurgie conservatrice</term><term>Tumeurs du sein</term><term>Volume</term><term>Glande mammaire</term><term>Sein</term><term>Peau</term><term>Avant bras</term><term>Derme</term><term>Creux axillaire</term><term>Traitement</term><term>Cancer du sein</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Purpose: To investigate lymphatic drainage as measured by lymphoscintigraphy in the arms of patients undergoing either sentinel lymph node biopsy (SNB) or axillary lymph node dissection (ALND). Material and Methods: From January 2001 to December 2002, 30 patients with unilateral invasive breast carcinoma underwent breast-conserving surgery with SNB and 30 patients with ALND. All patients received radiotherapy to the breast. Lymphoscintigraphy was performed, and skin circulation, skin temperature, and arm volume were measured 2-3 years after radiotherapy. Results: None of the 30 patients who underwent SNB showed any clinical manifestation of lymphedema. Of the 30 patients undergoing ALND, six (20%) had clinical lymphedema, with an arm volume that was >10% larger on the operated than on the non-operated side (P<0.01). Scintigraphically, visual analysis revealed lymphatic dysfunction in three patients, manifested as forearm dermal back flow. Two of these patients also had an increased arm volume. Quantitative analysis showed no differences between the groups, apart from a smaller amount of isotope in the axilla in the ALND group. There was no difference in skin circulation or skin temperature. Conclusion: Our study shows that lymph drainage in the operated arm compared with the non-operated arm was less affected by SNB than by ALND, and that morbidity associated with SNB was lower than with ALND. However, the results do not confirm our hypothesis that lymphoscintigraphy can reveal differences in lymph circulation that are not evident clinically in the form of manifest lymphedema. The most sensitive clinical method of assessing lymph drainage seems to be measurement of arm volume.</div></front></TEI><affiliations><list><country><li>Suède</li></country><region><li>Svealand</li></region><settlement><li>Stockholm</li></settlement></list><tree><noCountry><name sortKey="Danielsson, R" sort="Danielsson, R" uniqKey="Danielsson R" first="R." last="Danielsson">R. Danielsson</name><name sortKey="Frisell, J" sort="Frisell, J" uniqKey="Frisell J" first="J." last="Frisell">J. Frisell</name><name sortKey="Grondal, E" sort="Grondal, E" uniqKey="Grondal E" first="E." last="Grondal">E. Grondal</name><name sortKey="Perbeck, L" sort="Perbeck, L" uniqKey="Perbeck L" first="L." last="Perbeck">L. Perbeck</name><name sortKey="Svensson, L" sort="Svensson, L" uniqKey="Svensson L" first="L." last="Svensson">L. Svensson</name></noCountry><country name="Suède"><region name="Svealand"><name sortKey="Celebioglu, F" sort="Celebioglu, F" uniqKey="Celebioglu F" first="F." last="Celebioglu">F. Celebioglu</name></region><name sortKey="Celebioglu, F" sort="Celebioglu, F" uniqKey="Celebioglu F" first="F." last="Celebioglu">F. Celebioglu</name><name sortKey="Celebioglu, F" sort="Celebioglu, F" uniqKey="Celebioglu F" first="F." last="Celebioglu">F. Celebioglu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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